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3.2.6 Emerging reviews and mechanistic syntheses point toward cardiorenal, musculoskeletal, and multisystem expansion, but many proposed indications remain exploratory Recent reviews consistently describe a therapeutic expansion beyond diabetes and obesity into cardiovascular disease, renal protection, NAFLD, neurodegenerative disease, inflammation, hypertension, arthritis, and other conditions (Nauck et al., 2021), (Zheng et al., 2024), (Drucker, 2025)